New compounds, their preparation and use

专利名称：New compounds, their preparation and use发明人：PER SAUERBERG,LONE JEPPESEN,JOHN

PATRICK MOGENSEN,INGRIDPETTERSSON,PAU STANLEY BURY

申请号：AU4827901申请日：20010406公开号：AU4827901A公开日：20011030

摘要：The present invention relates to compounds of the general formula (I). Thecompounds are useful in the treatment and/or prevention of conditions mediated bynuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR),wherein R<1>, R<2>, R<3> and R<4> independently of each other are hydrogen, C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, aryl, aralkyl, heteroaryl, heteroaralkyl or C1-6-alkoxyC1-6-alkyl, optionally substituted with one or more halogen, hydroxy or amino;and X1, X2, X3 and X4 independently of each other is carbon, oxygen, sulphur or nitrogen;and Y is C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, aryl, aralkyl, alkylaralkyl, heteroaryl,heteroaralkyl, or alkylheteroaralkyl, optionally substituted with one or more halogen,hydroxy or amino; and Ar<1> and Ar<2> independently of each other are aryl orheteroaryl optionally substituted with one or more halogen, hydroxy, amino, aminoalkyl,carboxyalkyl, C1-6-alkyl or C1-6-alkoxy; or a salt thereof with a pharmaceuticallyacceptable acid or base, or any optical isomer or mixture of optical isomers, including aracemic mixture, or any tautomeric forms.

申请人：NOVO-NORDISK A/S

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